Open Access<p>Omics-Driven Biomarkers of Psoriasis: Recent Insights, Current Challenges, and Future Prospects</p>
Author(s) -
Büşra Aydın,
Kazım Yalçın Arğa,
Ayşe Serap Karadağ
Publication year - 2020
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s227896
Subject(s) - omics , psoriasis , biomarker , personalized medicine , biomarker discovery , context (archaeology) , epigenomics , precision medicine , computational biology , metabolomics , medicine , diagnostic biomarker , bioinformatics , proteomics , biology , pathology , immunology , genetics , gene , paleontology , gene expression , dna methylation
Advances in omics technologies have made it possible to unravel biomarkers from different biological levels. Intensive studies have been carried out to uncover the dysregulations in psoriasis and to identify molecular signatures associated with the pathogenesis of psoriasis. In this review, we presented an overview of the current status of the omics-driven biomarker research and emphasized the transcriptomic, epigenomic, proteomic, metabolomic, and glycomic signatures proposed as psoriasis biomarkers. Furthermore, insights on the limitations and future directions of the current biomarker discovery strategies were discussed, which will continue to comprehend broader visions of psoriasis research, diagnosis, and therapy especially in the context of personalized medicine.