Open Access<p>Interferon Kappa Is Up-Regulated in Psoriasis and It Up-Regulates Psoriasis-Associated Cytokines in vivo</p>
Author(s) -
Yuanyuan Li,
Yueqi Song,
Leqing Zhu,
Xiao Wang,
Bin Yang,
Ping Lü,
Quan Chen,
Lianghua Bin,
Liehua Deng
Publication year - 2019
Publication title -
clinical, cosmetic and investigational dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 35
ISSN - 1178-7015
DOI - 10.2147/ccid.s218243
Subject(s) - psoriasis , interferon , immunology , keratinocyte , epidermis (zoology) , tumor necrosis factor alpha , atopic dermatitis , interferon gamma , medicine , biology , immune system , in vitro , biochemistry , anatomy
There is increased type I interferon signature in psoriasis patients. Interferon-kappa (IFN-κ) is a member of type I interferon family that is constitutively expressed by keratinocytes. In this study, we investigate whether IFN-κ is involved in psoriasis etiology.