Open AccessAnalysis of Increased EGFR and IGF-1R Signaling and Its Correlation with Socio-Epidemiological Features and Biological Profile in Breast Cancer Patients: A Study in Northern Brazil
Author(s) -
Francianne Silva Rocha,
Jersey Heitor da Silva Maués,
Cynthia Mara Brito Lins Pereira,
Caroline Aquino Moreira-Nunes,
Rommel Rodrı́guez Burbano
Publication year - 2021
Publication title -
breast cancer
Language(s) - English
Resource type - Journals
ISSN - 1179-1314
DOI - 10.2147/bctt.s308554
Subject(s) - medicine , breast cancer , oncology , surgical oncology , epidemiology , epidermal growth factor receptor , correlation , pathological , cancer , survival analysis , insulin like growth factor , receptor , pathology , growth factor , geometry , mathematics
Breast cancer (BC) is the second most frequent cancer worldwide. It is known that a subset of BC has amplification, and overexpression of the epidermal growth factor receptor (EGFR) and high expression of the insulin-like growth factor receptor-1 (IGF-1R) are correlated with a favorable prognosis. This study aimed to evaluate the prognostic and predictive values of the EGFR and IGF-1R in tumor samples from patients with BC and their correlation with socio-epidemiological features.