Open Access<p>Inhibition of Yes-Associated Protein-1 (YAP1) Enhances the Response of Invasive Breast Cancer Cells to the Standard Therapy</p>
Author(s) -
Maha Guimei,
Sana Alrouh,
Maha Saber-Ayad,
Shirin Hafezi,
Arya Vinod,
Surendra Rawat,
Yazan Wardeh,
Tala Mohamad Bakkour,
Ahmed T. ElSerafi
Publication year - 2020
Publication title -
breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.19
H-Index - 27
ISSN - 1179-1314
DOI - 10.2147/bctt.s268926
Subject(s) - homeobox protein nanog , cancer research , breast cancer , yap1 , immunohistochemistry , cancer , medicine , sox2 , cancer stem cell , cancer cell , tissue microarray , hippo signaling pathway , surgical oncology , pathology , biology , oncology , immunology , embryonic stem cell , transcription factor , induced pluripotent stem cell , gene , biochemistry , effector
The deregulation of the Hippo pathway results in translocation ofYes-associated protein-1 (YAP1) to the nucleus to exert an oncogenic effect. This effect has been demonstrated in several malignancies, yet, in breast cancer (BC), it remains controversial. The present study aimed to investigate the significance of YAP1 expression in BC, its relation to cancer stem cells (CSCs), and the effect of its inhibition on tumor cell survival.