Open Access<p>Immunotherapy for the Treatment of Breast Cancer: Emerging New Data</p>
Author(s) -
Lida A. Mina,
Shan Lim,
Shakeela Bahadur,
Abdul T Firoz
Publication year - 2020
Publication title -
breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.19
H-Index - 27
ISSN - 1179-1314
DOI - 10.2147/bctt.s184710
Subject(s) - medicine , breast cancer , immunotherapy , triple negative breast cancer , oncology , cancer , surgical oncology , targeted therapy , lung cancer , melanoma , cancer immunotherapy , disease , cancer research , immunology
Breast cancer is the most common type of cancer affecting women in the United States. Triple-negative breast cancer remains the most aggressive molecular subtype secondary to a lack of therapeutic targets. The search for a target has led us to investigate immunotherapeutic agents. Immunotherapy has recently demonstrated significant breakthroughs in various types of cancers that are refractory to traditional therapies including melanoma and Non-Small Cell Lung Cancer (NSCLC). Breast cancer however remains one of the tumors that was initially least investigated because of being considered to have a low immunogenic potential and a low mutational load. Over the past few years, antiPD1/PDL1 drugs have started to make progress in the triple-negative subtype with more promising outcomes. In this report, we review the treatment of triple-negative breast cancer and specifically shed light on advances in immunotherapy and newly approved drugs in this challenging disease.