Open AccessLeptin is Associated with the Tri-Ponderal Mass Index in Children: A Cross-Sectional Study
Author(s) -
Brianna Empringham,
William Jennings,
Raeesha Rajan,
Adam Fleming,
Carol Portwine,
Donna L. Johnston,
Shayna Zelcer,
Shahrad R. Rassekh,
Victoria Tran,
Sarah Burrow,
Lehana Thabane,
M. Constantine Samaan
Publication year - 2021
Publication title -
adolescent health, medicine and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 1179-318X
DOI - 10.2147/ahmt.s289973
Subject(s) - leptin , percentile , medicine , body mass index , obesity , cross sectional study , biomarker , mass index , endocrinology , statistics , mathematics , biology , pathology , biochemistry
Obesity is characterized by the disproportionate expansion of the fat mass and is most commonly diagnosed using the Body Mass Index (BMI) z-score or percentile in children. However, these measures associate poorly with the fat mass. This is important, as adiposity is a more robust predictor of cardiometabolic risk than BMI-based measures, but there are limited clinical measures of adiposity in children. A new measure, the Tri-ponderal Mass Index (TMI, kg/m 3 ) has recently demonstrated robust prediction of adiposity in children. The aim of this study is to explore the association of leptin, a validated biomarker of the fat mass, with TMI.