Open AccessComparative Structural Analysis of Human ACE2 Receptor with Spike Protein of SARS-CoV-2 Variants: Implications to Understand Infectivity of the Virus
Author(s) -
Tirthankar Koley,
Arunima Goswami,
Manoj Kumar,
Neelam Upadhyay,
Gururao Hariprasad
Publication year - 2022
Publication title -
advances and applications in bioinformatics and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.223
H-Index - 15
ISSN - 1178-6949
DOI - 10.2147/aabc.s360787
Subject(s) - spike protein , protein data bank (rcsb pdb) , spike (software development) , biology , uniprot , protein structure , receptor , infectivity , protein domain , wild type , genetics , computational biology , virus , gene , covid-19 , mutant , biochemistry , medicine , disease , management , pathology , infectious disease (medical specialty) , economics
Spike protein on SARS-CoV-2 virus plays an integral part during infection as cell entry depends on binding of this protein to human ACE2 receptor. Understanding of infectivity by these variants necessitates a comparative structural analysis of complexes of spike protein-receptor binding domain (RBD) of these variants to receptor.