Open AccessSerum Periostin Level Reflects Progression of Ossification of the Posterior Longitudinal Ligament
Author(s) -
Yoshiharu Kawaguchi,
Isao Kitajima,
Taketoshi Yasuda,
Shoji Seki,
Kayo Suzuki,
Hiroto Makino,
Yasuhiro Ujihara,
Takahiro Ueno,
Nguyen Tran Canh Tung,
Yasuhito Yahara
Publication year - 2022
Publication title -
jb and js open access
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.786
H-Index - 3
ISSN - 2472-7245
DOI - 10.2106/jbjs.oa.21.00111
Subject(s) - periostin , ossification of the posterior longitudinal ligament , ossification , medicine , anatomy , biology , microbiology and biotechnology , extracellular matrix , myelopathy , psychiatry , spinal cord
Ossification of the posterior longitudinal ligament (OPLL), characterized by ectopic new bone formation in the spinal ligament, causes neurological impairment due to narrowing of the spinal canal. However, the etiology has not been fully elucidated yet. Several biomarkers may be related to the pathogenesis of OPLL. The present study focused on the serum level of periostin, which is recognized as an important bone formation regulator.