Open AccessApplication of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Author(s) -
DungTsa Chen,
Michael J. Schell,
William J. Fulp,
Fredrik Pettersson,
Sungjune Kim,
Jhanelle E. Gray,
Eric B. Haura
Publication year - 2019
Publication title -
translational cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.254
H-Index - 30
eISSN - 2219-6803
pISSN - 2218-676X
DOI - 10.21037/tcr.2019.05.17
Subject(s) - bayesian probability , posterior probability , computer science , interim analysis , statistical power , prior probability , sample size determination , statistics , artificial intelligence , clinical trial , mathematics , medicine , pathology
Bayesian predictive probability design, with a binary endpoint, is gaining attention for the phase II trial due to its innovative strategy. To make the Bayesian design more accessible, we elucidate this Bayesian approach with a R package to streamline a statistical plan, so biostatisticians and clinicians can easily integrate the design into clinical trial.