Open AccessA narrative review of genetic factors affecting fluoropyrimidine toxicity
Author(s) -
William H. Gmeiner
Publication year - 2021
Publication title -
precision cancer medicine
Language(s) - English
Resource type - Journals
ISSN - 2617-2216
DOI - 10.21037/pcm-21-17
Subject(s) - dpyd , dihydropyrimidine dehydrogenase , medicine , pharmacogenomics , toxicity , oncology , pharmacogenetics , colorectal cancer , neutropenia , fluorouracil , pharmacology , cancer , bioinformatics , genotype , biology , thymidylate synthase , genetics , gene
Our objective is to document progress in developing personalized therapy with fluoropyrimidine drugs (FPs) to improve outcomes for cancer patients and to identify areas requiring further investigation.