Open AccessRecombinant human bone morphogenetic protein-2 in spine surgery: recommendations for use and alternative bone substitutes—a narrative review
Author(s) -
Gregory M. Malham,
Philip K. Louie,
Graeme A. Brazenor,
Ralph J. Mobbs,
William R. Walsh,
Rajiv Sethi
Publication year - 2022
Publication title -
journal of spine surgery
Language(s) - English
Resource type - Journals
eISSN - 2414-469X
pISSN - 2414-4630
DOI - 10.21037/jss-22-23
Subject(s) - bone morphogenetic protein , human bone , recombinant dna , bone morphogenetic protein 2 , narrative review , medicine , biology , intensive care medicine , biochemistry , gene , in vitro
Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been extensively studied in preclinical, animal, and human studies and has been used widely in spine fusion surgery. Evidence demonstrates that fusion rates with rhBMP-2 are similar to or higher than those achieved with autologous bone graft. However, there have been concerns regarding the cost, optimal dosage, and potential complications of rhBMP-2 use in spine surgery. The objective of this paper is to provide a current review of the available evidence regarding rhBMP-2 and other bone graft substitutes used for spinal surgery.