Open AccessQuantitative metric for assessment of pancreatic ductal adenocarcinoma treatment response in T1-weighted gadolinium-enhanced magnetic resonance imaging
Author(s) -
Joy Liau,
Srinivasan Vedantham,
Hani M. Babiker,
Travis McGlothin,
Diego R. Martín
Publication year - 2020
Publication title -
annals of pancreatic cancer
Language(s) - English
Resource type - Journals
ISSN - 2616-2741
DOI - 10.21037/apc-20-25
Subject(s) - magnetic resonance imaging , medicine , gadolinium , nuclear medicine , metric (unit) , pancreatic ductal adenocarcinoma , radiology , pancreatic cancer , gastroenterology , cancer , chemistry , organic chemistry , operations management , economics
We theoretically derived a new quantitative metric reflecting the product of T1 signal intensity and contrast media concentration ( T1C ) using first principles for the signal provided by the gradient echo sequence. This metric can be used with conventional gadolinium contrast-enhanced magnetic resonance imaging (CE-MRI) exams. We used this metric to test our hypothesis that gadolinium enhancement changes with pancreatic ductal adenocarcinoma (PDA) treatment response, and that this metric may differentiate responders from non-responders.