Open AccessProximal esophageal contraction after induction of ineffective distal contraction by sildenafil in healthy volunteers
Author(s) -
Tarciana Vieira Costa,
Roberto Oliveira Dantas
Publication year - 2019
Publication title -
annals of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 33
eISSN - 1792-7463
pISSN - 1108-7471
DOI - 10.20524/aog.2019.0443
Subject(s) - sildenafil , medicine , esophagus , contraction (grammar) , muscle contraction , cardiology , motility , peristalsis , anatomy , endocrinology , biology , genetics
Proximal esophagus is composed of striated muscle replaced by smooth muscle in the distal section. Sildenafil, an inhibitor of phosphodiesterase type 5, causes a decrease in the amplitude of contractions in distal smooth muscle esophagus, with no effect on the proximal esophageal striated muscle. The aim of this investigation was to evaluate the hypothesis that proximal contractions are affected by changes in distal contractions caused by sildenafil.