Open AccessOxaliplatin Induced Pulmonary Fibrosis: A Case Report
Author(s) -
Mirjana Pavlović,
Robert Šeparović,
Tajana Silovski,
Ana Tečić Vuger,
Andreja Jurič
Publication year - 2020
Publication title -
acta clinica croatica
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 20
eISSN - 1333-9451
pISSN - 0353-9466
DOI - 10.20471/acc.2020.59.04.25
Subject(s) - oxaliplatin , medicine , folfox , regimen , chemotherapy , pulmonary fibrosis , fibrosis , oncology , gastroenterology , colorectal cancer , cancer
Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.