Open AccessThe Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals
Author(s) -
Kristina Blaslov,
Domagoj Gajski,
Vesna Vucelić,
Petar Gaćina,
Gorana Mirošević,
Jelena Marinković,
Milan Vrkljan,
Krešimir Rotim
Publication year - 2020
Publication title -
acta clinica croatica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 20
eISSN - 1333-9451
pISSN - 0353-9466
DOI - 10.20471/acc.2020.59.04.16
Subject(s) - euthyroid , medicine , thyroid peroxidase , subclinical infection , thyroiditis , insulin resistance , endocrinology , thyroid , autoimmune thyroiditis , thyroglobulin , anti thyroid autoantibodies , autoimmunity , insulin , immunology , antibody , autoantibody , disease
Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. The degree of IR was evaluated by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). The Hashimoto thyroiditis group had higher HOMA-IR (p=0.003) and lower glucose levels (p=0.04). HOMA-IR correlated positively with anti-TPO (p<0.001). Linear logistic regression revealed that anti-TPO concentration increased by 18.13 (p=0.001) with each HOMA-IR unit. IR might trigger thyroid antibody production and Hashimoto thyroiditis development, which needs to be evaluated in further larger scale follow up studies.