Open AccessRelationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth
Author(s) -
Lidija Banjac,
Jelena KoturStevuljević,
Tamara Gojković,
Vesna Bokan-Mirković,
Goran Banjac,
Gorica Banjac
Publication year - 2020
Publication title -
acta clinica croatica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.274
H-Index - 20
eISSN - 1333-9451
pISSN - 0353-9466
DOI - 10.20471/acc.2020.59.01.11
Subject(s) - percentile , insulin like growth factor , medicine , birth weight , gestational age , growth factor , significant difference , reference range , placental insufficiency , endocrinology , fetus , pregnancy , placenta , biology , statistics , receptor , mathematics , genetics
Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33 rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33 rd pmw to be 23.1±4.56 (range 15.44-39.75) µg/L. There was no difference in IGF-1 values between male (23.1±4.98 µg/L) and female (23.1±4.87 µg/L) newborns. There was no significant difference in the average IGF-1 levels between male and female newborns with BW <50 th and BW >50 th percentile for GA either (p>0.50). Only BW <33 rd percentile newborns had a statistically significantly lower IGF-1 level compared to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33 rd percentile newborns. This fact could be used for further therapeutic purposes.