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This study was designed to assess the efficacy of a matrix metalloproteinase inhibitor in prolonging posttreatment survival for dogs with appendicular osteosarcoma after treatment with amputation and doxorubicin chemotherapy.

Doxorubicin and BAY 12-9566 for the Treatment of Osteosarcoma in Dogs: A Randomized, Double-Blind, Placebo-Controlled Study