Open AccessVascular Endothelial Growth Factor Genetic Variant is Associated with In-Stent Restenosis after Percutaneous Coronary Intervention
Author(s) -
Saeedeh Asgarbeik,
Aida Vahidi,
Mandana Hasanzad,
Mojgan Asadi,
Mahsa M. Amoli
Publication year - 2022
Publication title -
the journal of tehran university heart center./the journal of tehran university heart center
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.182
H-Index - 13
eISSN - 2008-2371
pISSN - 1735-8620
DOI - 10.18502/jthc.v17i3.10844
Subject(s) - restenosis , percutaneous coronary intervention , medicine , genotype , allele , vascular endothelial growth factor , cardiology , pathogenesis , stent , gene , vegf receptors , genetics , biology , myocardial infarction
In-stent restenosis (ISR) is an inevitable complication of percutaneous coronary intervention, with genetic factors thought to play a role in its pathogenesis. The vascular endothelial growth factor (VEGF) gene can have an inhibitory effect on ISR development. Accordingly, in the present study, we investigated the role of -2549 VEGF (insertion/deletion [I/D]) variants in ISR formation.