Open AccessCombined Application of Platelet-Rich Plasma and Biocomposite Material Collapan in Complex Treatment of Patients with Non-United Fractures and Pseudarthrosis of Extremity Long Bones
Author(s) -
G. A Kesyan,
G N Berchenko,
R Z Urazgil'deev,
D S Mikelaishvili,
B N Shulashоv,
G. A Kesyan,
B N Shulashоv
Publication year - 2011
Publication title -
vestnik travmatologii i ortopedii imeni n.n. priorova
Language(s) - English
Resource type - Journals
eISSN - 2658-6738
pISSN - 0869-8678
DOI - 10.17816/vto201118226-32
Subject(s) - pseudarthrosis , platelet rich plasma , bone healing , biocomposite , medicine , surgery , platelet , materials science , composite material , composite number
Nanostructural biocomposite material Collapan and platelet-rich autoplasma (PRP) were applied for the treatment of 158 patients with non-consolidating fractures and pseudarthrosis of extremities' long bones. It was shown that combined application of Collapan and PRP was available, safe and effective measure for activization of reparative bone regeneration. Consolidation of fractures and healing of pseudarthroses was achieved in 97.8% of patients. In control group (traditional surgical treatment) positive results was achieved in 81.4% of patients. Terms of fracture consolidation reduced by 11.0±2.3 days, of pseudarthroses healing - by 20±4.3 days. Nanostructural Collapan is a perfect matrix for isolation of autologous growth factors from platelets that contribute to fracture healing activization.