Open AccessAssessing chemical elements balance in patients with hypertension
Author(s) -
I.U. Tarmaeva,
S.U. Baglushkina,
Н. В. Ефимова
Publication year - 2016
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17750/kmj2015-501
Subject(s) - potassium , sodium , magnesium , cadmium , chemistry , zinc , chromium , medicine , population , calcium , essential hypertension , chloride , zoology , endocrinology , nuclear chemistry , blood pressure , biology , environmental health , organic chemistry
Aim. To assess the imbalance of the chemical elements in biological substrates in the adult population of Irkutsk suffering from hypertension.Methods. During the work performance, the data of 55 patients with hypertension including 40 women aged 41-66 years and 15 men aged 52-66 years living in the city of Irkutsk were investigated. During the study of the elemental status of patients with hypertension, determination of 25 elements content in the hair was performed. Analysis of the studied samples was conducted in the NGO «Center for Biotic Medicine» laboratory. 7 elements is determined by ion-selective method in the blood: K, Na, Mg, Fe, Cl, Ca, P.Results. Elemental status of patients with hypertension is characterized by a low content of essential elements - Ca (482±31.2 mg/kg), Zn (164±12 mg/kg) and Mg (154±3.3 mg/kg), significantly higher content of Na (553±156 mg/kg) in the hair; decrease in concentration of Mg (0.64±0.04 mmol/l) and Ca (2.01±0.05 mmol/l), increase in Na (149±4 mmol/l) and Cl (119.4±2.8 mmol/l) levels in blood. Increased content of chloride in blood serum, boron in the hair, potassium and lead in the hair (in men), a low content of cobalt in the hair (in men) and zinc (in women) were found; compared with men, in women lower contents of sodium in the blood serum, potassium, aluminum, cadmium and lead in the hair, a higher content of calcium, magnesium, chromium, silicon, vanadium and strontium in the hair were registered; the most pronounced correlation was observed between anthropometric parameters and the level of the chemical elements in biological samples.Conclusion. The result of assessing imbalance of the key elements in the blood is more informative than the data on selected elements, probably because the presence of any imbalance reflects either the complexity of the factor impact or the severity of the deficit or excess of one element, which caused shifts of microelement landscape as a whole.