Production of Immunobiological Preparations as a Prerequisite to Demographic Modernisation: a Case of Bacteriological Institute at the Perm Governorate Zemstvo

The article refers to the creation of a bacteriological station (1897), then an institute (1912) under the zemstvo of the Perm governorate. To combat microbes, it was necessary to produce vaccines and serum. These institutions were the first in Russia to produce immunobiological preparations. The emergence of a solid material base and experienced personnel of the institute was investi gated based on a historical-genetic method. In the pre-revolutionary period, employees of the institute established successful production of vaccines against rabies, scarlet fever, cholera, typhoid fever and smallpox, as well as serums against diphtheria, dysentery, scarlet fever.