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Gene expression studies from hematopoietic stem cell (HSC) populations purified to variable degrees have defined a set of stemness genes. Unexpectedly, results also hinted toward a HSC chromatin poised in a wide‐open state. With the aim of providing a robust tool for further studies into the molecular biology of HSCs, the studies herein describe the construction and comparative molecular analysis of λ‐phage cDNA libraries from highly purified HSCs that retained their long‐term repopulating activities (long‐term HSCs [LT‐HSCs]) and from short‐term repopulating HSCs that were largely depleted of these activities. Microarray analysis of the libraries confirmed the previous results but also revealed an unforeseen preferential expression of translation‐ and metabolism‐associated genes in the LT‐HSCs. Therefore, these data indicate that HSCs are quiescent only in regard of proliferative activities but are in a state of readiness to provide the metabolic and translational activities required after induction of proliferation and exit from the HSC pool.

stem cells

Gene Expression Profiles in Murine Hematopoietic Stem Cells Revisited: Analysis of cDNA Libraries Reveals High Levels of Translational and Metabolic Activities