Open AccessComparison of the Central and Peripheral Components of Action in Comprehensive Analgesic Activity of New Kappa-Agonist
Author(s) -
Viktor Batrakov,
D.D. Shamshina,
Andrey Ivanov
Publication year - 2018
Publication title -
vestnik volgogradskogo gosudarstvennogo universiteta. seriâ 11. estestvennye nauki
Language(s) - English
Resource type - Journals
eISSN - 2409-2762
pISSN - 2306-4153
DOI - 10.15688/jvolsu11.2018.1.5
Subject(s) - analgesic , peripheral , agonist , medicine , pharmacology , anesthesia , receptor
Elimination of the pain syndrome is still an urgent task in various fields of medicine. Therefore, the problem of finding new effective and safe analgesics remains today one of the most important. The research is aimed at comparing the central and peripheral analgesic activity of chemical mixture KOR 205 in an experiment in rats. Based on the results of the experimental work, indicators of the maximum possible effect (MVE%) have been determined. The KOR 205 compound has a more pronounced central analgesic effect, compared with peripheral analgesic activity.