Open AccessValidation of Genome-Wide Association Studies (GWAS)-Identified Type 2 Diabetes Mellitus Risk Variants in Pakistani Pashtun Population
Author(s) -
Asif Jan,
* Zakiullah,
Fazli Khuda,
Rani Akbar
Publication year - 2023
Publication title -
journal of the asean federation of endocrine societies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.153
H-Index - 3
eISSN - 2308-118X
pISSN - 0857-1074
DOI - 10.15605/jafes.037.s5
Subject(s) - tcf7l2 , genome wide association study , single nucleotide polymorphism , genetic association , snp , type 2 diabetes mellitus , population , genetics , medicine , type 2 diabetes , biology , oncology , diabetes mellitus , genotype , gene , endocrinology , environmental health
Recent GWAS largely conducted in European populations have successfully identified multiple genetic risk variants associated with Type 2 Diabetes Mellitus (T2DM). However, the effects conferred by these variants in the Pakistani population have not yet been fully elucidated. The objective of this study was to examine European GWAS-identified T2DM risk variants in the Pakistani Pashtun population to better understand the shared genetic basis of T2DM in the European and Pakistani cohorts.