Open AccessTreatment Outcome of a β-hCG Secreting Intracranial Germ Cell Tumor in an Adult Filipino using Definitive Chemotherapy followed by Radiotherapy: A Case Report
Author(s) -
Florence Rochelle Gan,
Maria Honolina S. Gomez,
Julie Ann Tapispisan
Publication year - 2022
Publication title -
journal of the asean federation of endocrine societies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.153
H-Index - 3
eISSN - 2308-118X
pISSN - 0857-1074
DOI - 10.15605/jafes.037.01.12
Subject(s) - medicine , headaches , diabetes insipidus , germinoma , radiation therapy , craniopharyngioma , germ cell tumors , surgery , weight loss , chemotherapy , polydipsia , weakness , radiology , endocrinology , diabetes mellitus , obesity
We report a case of a 24-year-old Filipino male who complained of general weakness, polydipsia, weight loss, bitemporal headaches, loss of libido and behavioral changes. Endocrine work-up revealed neurogenic diabetes insipidus and panhypopituitarism. Brain MRI showed multiple intracranial tumors in the left frontal lobe, pineal and suprasellar region with moderate non-communicating hydrocephalus. Intracranial mass biopsy with ventriculo-peritoneal shunting was done. Histopathology of the mass and CSF revealed a germinoma. He underwent chemoradiotherapy while on maintenance hormone replacement.