Open AccessChronic ethanol ingestion induces glomerular filtration barrier proteins genes expression alteration and increases matrix metalloproteinases activity in the kidney of rats
Author(s) -
Mahrokh Samadi,
Alireza Shirpoor,
Ali Afshari,
Fatemeh Kheradmand,
Yousef Rasmi,
Maryam Sadeghzadeh
Publication year - 2018
Publication title -
interventional medicine and applied science/interventional medicine and applied science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.195
H-Index - 14
eISSN - 2061-5094
pISSN - 2061-1617
DOI - 10.1556/1646.10.2018.23
Subject(s) - podocin , nephrin , medicine , endocrinology , matrix metalloproteinase , mmp2 , kidney , renal function , kidney disease , podocyte , proteinuria , metastasis , cancer
Chronic alcohol ingestion-induced kidney structure and function alterations are very well known, but the precise underlying molecular mediators involved in ethanol-induced kidney abnormalities remain elusive. The aim of this study was to investigate the effect of chronic ethanol exposure on matrix metalloproteinase 2, 9 (MMP), glomerular filtration barrier proteins (nephrin and podocin), as well as vascular endothelial growth factor receptor 1, 2 (VEGFRs) isoforms gene expression in the kidney of rats.