Open AccessAssociation of Alzheimer’s disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies
Author(s) -
Sriram Kaliamoorthy,
Mahendirakumar Nagarajan,
Vijayparthiban Sethuraman,
Kavitha Jayavel,
Vijayalakshmi Lakshmanan,
Santosh Palla
Publication year - 2022
Publication title -
medicine and pharmacy reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.35
H-Index - 16
eISSN - 2668-0572
pISSN - 2602-0807
DOI - 10.15386/mpr-2278
Subject(s) - meta analysis , systematic review , odds ratio , periodontitis , observational study , confidence interval , medicine , disease , medline , publication bias , biology , biochemistry
The relationship between periodontitis (or periodontal disease) with Alzheimer’s disease has been reported by various primary sources in the past decade, but not with a solid secondary research statement. A systematic review and meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered (Reference number: CRD42020185264) with PROSPERO (International prospective register for systematic reviews). A literature search was conducted on specific databases for suitable articles in English language. Out of 612 studies selected, 41 underwent full-text analysis; five studies were eligible for systematic review, and 3 for meta-analysis. Meta-analysis was performed with tests for sensitivity and statistical heterogeneity followed by calculation of summary effect measures in terms of odds ratio (OR) and 95% confidence interval (CI). The results of this review showed a significant association between periodontitis and Alzheimer’s disease in the meta-analysis [OR 1.67 (1.21–2.32)].