Open AccessSignet ring cell gastric carcinoma with breast and leptomeningeal metastases: a case report
Author(s) -
Tiberiu Rareș Moldovan,
Călin Căinap,
Zsolt Fekete,
Emil Puscaş,
Andrei Roman,
Rareş Buiga,
Diana Olteanu,
Mădălina Bota,
Simona Căinap,
Ovidiu Vasile Bochis
Publication year - 2022
Publication title -
medicine and pharmacy reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.35
H-Index - 16
eISSN - 2668-0572
pISSN - 2602-0807
DOI - 10.15386/mpr-1654
Subject(s) - signet ring cell , medicine , signet ring cell carcinoma , malignancy , chemotherapy , cancer , breast cancer , oncology , histology , pathology , breast carcinoma , invasive lobular carcinoma , adenocarcinoma , invasive ductal carcinoma
Gastric cancer is the 5th most common malignancy worldwide. Signet ring cell histology represents an aggressive subtype of gastric cancer, presenting at a younger age. Both breast and leptomeningeal metastases are rare locations of tumor dissemination, requiring correct and immediate diagnosis and treatment. We present a case of a 45-year old female with signet ring cell gastric carcinoma who developed both left breast and leptomeningeal metastases, requiring multiple chemotherapy lines. As far as we know, this is the first published case in literature following multiple lines of treatment for both breast and leptomeningeal metastases from signet ring cell gastric carcinoma.