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Objective  Plasma glucose has been correlated with in-hospital mortality among many diseases including infections. We aimed to study the plasma glucose at the admission of hospitalized patients with COVID-19 at a tertiary care referral hospital at Jodhpur, India and its relation with mortality.    Design   A hospital-based clinical study of plasma glucose of COVID-19 patients conducted from May 15 to June 30, 2020 after ethical approval.    Measurements   Random blood samples at admission were collected for plasma glucose, interleukin-6 (IL6) and high sensitivity C-reactive protein (hsCRP) after written informed consent was obtained. Plasma glucose was analyzed by the automated analyzer, IL6 by chemiluminescent immunoassay and hsCRP by immune-turbidimetric assay.    Results  A total of 386 patients were studied (female 39.6%); 11.1% had severe disease and 4.1% expired. There were 67 (17.4%) patients with known diabetes mellitus (DM). Patients with a history of DM had three times higher mortality (6/67, 9%) than those without DM (10/309, 3.1%). Patients with moderate and severe disease according to ICMR and WHO grading had higher plasma glucose than those with asymptomatic or mild disease ( P   100–200, &gt;200–300 and &gt;300 mg/dL, respectively, compared to those with random plasma glucose of &lt;100 mg/dL at admission. Plasma glucose was strongly correlated with hsCRP ( P  &lt; 0.001) and IL6 ( P  &lt; 0.0001).    Conclusions   Plasma glucose at admission in hospitalized COVID-19 patients is a strong predictor of mortality.

Effect of plasma glucose at admission on COVID-19 mortality: experience from a tertiary hospital