English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Perception of microbe‐associated molecular patterns by host cell surface pattern recognition receptors ( PRR s) triggers the intracellular activation of mitogen‐activated protein kinase ( MAPK ) cascades. However, it is not known how  PRR s transmit immune signals to  MAPK  cascades in plants. Here, we identify a complete phospho‐signaling transduction pathway from  PRR ‐mediated pathogen recognition to  MAPK  activation in plants. We found that the receptor‐like cytoplasmic kinase  PBL 27 connects the chitin receptor complex  CERK 1‐ LYK 5 and a  MAPK  cascade.  PBL 27 interacts with both  CERK 1 and the  MAPK  kinase kinase  MAPKKK 5 at the plasma membrane. Knockout mutants of   MAPKKK 5  compromise chitin‐induced  MAPK  activation and disease resistance to  Alternaria brassicicola .  PBL 27 phosphorylates  MAPKKK 5  in vitro , which is enhanced by phosphorylation of  PBL 27 by  CERK 1. The chitin perception induces disassociation between  PBL 27 and  MAPKKK 5  in vivo . Furthermore, genetic evidence suggests that phosphorylation of  MAPKKK 5 by  PBL 27 is essential for chitin‐induced  MAPK  activation in plants. These data indicate that  PBL 27 is the  MAPKKK  kinase that provides the missing link between the cell surface chitin receptor and the intracellular  MAPK  cascade in plants.

The Arabidopsis CERK 1‐associated kinase PBL 27 connects chitin perception to MAPK activation