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It's cold, mom! It's cyclic GMP
Author(s) -
Kuhn Michaela
Publication year - 2015
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201490639
Subject(s) - soluble guanylyl cyclase , second messenger system , receptor , guanylate cyclase , transmembrane protein , biology , nitric oxide , cyclase , microbiology and biotechnology , biochemistry , endocrinology
Cyclic GMP is the signal transducer of a family of transmembrane, particulate guanylyl cyclase ( GC ) receptors with key roles in physiology and disease. GC ‐G, the last member of the membrane GC s identified in mammals, is an orphan receptor and its regulation and function have remained largely unknown. In this issue of The EMBO Journal , Chao et al ([Chao YC, 2015]) show that the GC ‐G/ cGMP pathway, which is expressed in a specific cluster of olfactory neurons of neonatal mice, functions as a cold‐induced thermosensor, which triggers protective maternal care.