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Objective:  is a member of the    Method:  The present paper was carried out to compare the toxic effect of oral administration of    Results:  Significant differences were observed in the level of the ALT, AST, BUN and creatinine. Interestingly, the biochemical changes were more severe in AST in rats compared with mice (15–16 and 4–5 times compared to control, respectively). In comparison, the values of BUN in rats were higher compared with mice (2–2.5 and 1–1.5 times, respectively). In mice and in rat more sever toxic lesions were observed in the liver and kidney, respectively.    Conclusion:  In conclusion, the biochemical and pathological results of the current study suggested that mice have more susceptibility to hepatotoxicity of

turkish journal of biochemistry

Experimental  Nerium oleander  poisoning in Balb/c mice and Wistar rat: comparative hepatotoxicity and nephrotoxicity effects based on biochemical and pathological studies