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Objective:  The aim of this study was to investigate serum and tissue levels of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) and to evaluate correlations between serum and tissue parameters with respect to clinicopathological features in patients with lung cancer.    Methods:  The study was conducted on 34 patients with stage I-IV primary lung cancer and 32 healthy controls. Preoperative serum, tumor and matched normal tissue VEGF, Ang-1 and Ang-2 levels were determined with ELISA.    Results:  Serum Ang-2 levels were significantly increased in lung cancer patients (p&lt;0.001). VEGF levels were significantly higher in tumor tissue than in matched normal tissue (p&lt;0.001). Ang-1 and Ang-2 levels were significantly higher in normal tissue than in tumor tissue (p&lt;0.001). A significant negative correlation was found between normal lung tissue Ang-2 and serum VEGF levels (r=−0.400, p=0.019). A significant correlation was observed between serum and lung tissue Ang-2 levels (r=0.397, p=0.020).    Conclusion:  This study clearly demonstrated that VEGF, Ang-1 and Ang-2 are all involved in lung cancer process. This was the first study to show a correlation between serum and tissue levels of Ang-2 in lung cancer. This finding might be the basis for therapeutic strategies against lung cancer.

turkish journal of biochemistry

Evaluation of angiogenesis with serum and tissue vascular endothelial growth factor, angiopoietin-1 and angiopoietin-2 levels in relation to clinicopathological features in lung cancer patients