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Production of high specific activity  186g Re is of interest for development of theranostic radiopharmaceuticals. Previous studies have shown that high specific activity  186g Re can be obtained by cyclotron irradiation of enriched  186 W via the  186 W(d,2n) 186g Re reaction, but most irradiations were conducted at low beam currents and for short durations. In this investigation, enriched  186 W metal targets were irradiated at high incident deuteron beam currents to demonstrate production rates and contaminants produced when using thick targets. Full-stopping thick targets, as determined using SRIM, were prepared by uniaxial pressing of powdered natural abundance W metal or 96.86% enriched  186 W metal encased between two layers of graphite flakes for target material stabilization. An assessment of structural integrity was made on each target preparation. To assess the performance of graphite-encased thick  186 W metal targets, along with the impact of encasing on the separation chemistry, targets were first irradiated using a 22 MeV deuteron beam for 10 min at 10, 20, and 27 μA, with an estimated nominal deuteron energy of 18.7 MeV on the  186 W target material (after energy degradation correction from top graphite layer). Gamma-ray spectrometry was performed post EOB on all targets to assess production yields and radionuclidic byproducts. The investigation also evaluated a method to recover and recycle enriched target material from a column isolation procedure. Material composition analyses of target materials, pass-through/wash solutions and recycling process isolates were conducted with SEM, FTIR, XRD, EDS and ICP-MS spectrometry. To demonstrate scaled-up production, a graphite-encased  186 W target made from recycled  186 W was irradiated for ~2 h with 18.7 MeV deuterons at a beam current of 27 μA to provide 0.90 GBq (24.3 mCi) of  186g Re, decay-corrected to the end of bombardment. ICP-MS analysis of the isolated  186g Re solution provided data that indicated the specific activity of  186g Re in this scaled-up production run was 2.6±0.5 GBq/μg (70±10 Ci/mg).

radiochimica acta

Scale-up of high specific activity  186g Re production using graphite-encased thick  186 W targets and demonstration of an efficient target recycling process