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Oxidant agents used for top-decontamination in cytotoxic reconstitution units may spread into IV bags. The amount of hydrogen peroxide passing through the bags and its release have been evaluated using wrapped or unwrapped infusion bags made of three layers of polyolefin (Freeflex    Methods  3 experiments were carried out using 2 packages of 30 bags of polyolefin with (package A) or without (package B) overwrapping. A 43 min decontamination cycle with H    Results  A linear calibration curve over the concentration range of 0.00–2.70 ppm was used prior to each analysis. The concentration of H    Conclusion/Discussion  These results allow removing overwrapping for a lean production system, with an extemporaneous use. However, the graduate release of H

Permeability and Release of Decontaminating Agent Used in Cytotoxic Reconstitution Units: Diffusion of Hydrogen Peroxide in IV Bags