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The design of new chemical reactions that are convenient, sustainable, and innovative is a preeminent concern for modern synthetic chemistry. While the use of earth abundant element catalysts remains underdeveloped by chemists, nature has developed a cornucopia of powerful transformation using only base metals, demonstrating their viability for sustainable method development. Here we show how study of nature’s approach to disparate chemical problems, from alkene desaturation to photodetection in bacteria, can inspire and enable new approaches to difficult synthetic chemistry problems past, present, and future.

A blueprint for green chemists: lessons from nature for sustainable synthesis