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Epilobium  genus has been confirmed as an effective source of natural antimicrobials. However, the influence of  Epilobi hirsuti herba  derived products on usual antibiotics activity has not been studied. In this study, several standardized Epilobi  hirsuti herba extracts  (EHE) were evaluated in order to asses their potential effects on usual antibiotics tested on standard Gram-positive and Gram-negative bacterial strains  in vitro . The results emphasized that the bacterial strains ranged from sensitive (MIC values between 50–200 μg GAE mL -1 ) ( S. epidermidis  ATCC 12228) to very resistant ( E. coli  strains),  E. faecalis  ATCC 29212 being practically immune to EHE. In terms of synergistic interaction, Tetracycline and Ampicillin combinations lead to the most important stimulatory effects, the diameters of the inhibition zone being even 60% bigger compared to the antibiotic alone. Synergistic effects between myricetin(galloyl) derivates and Tetracycline were also revealed on  P. aeruginosa  and  E. coli  strains. Together, it clearly demonstrated not only EHE’s own antimicrobial properties, but also their capacity to influence the antimicrobial potency of some common antibiotics. These results could be useful for the area of herbal medicines and as potential candidates in managing microbial resistance, but also for physicians and pharmacists using combined antibacterial therapy.

Epilobi Hirsuti Herba Extracts Influence the In Vitro Activity of Common Antibiotics on Standard Bacteria