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This paper addresses the effects of the concentration of lipases, temperature and solvent on the enzymatic acetylation of primary amines. (±)-Heptan-2-amine 1, (±)-4-phenylbutan-2-amine 2, (±)-1,2,3,4-tetrahydronaphthalen-1-amine 3 and (±)-2-methylcyclohexan-1-amine 4 were acetylated using 11 lipases to obtain amides under orbital shaking and microwave radiation. Under microwave radiation the same amines were acetylated only using the CALB. (±)-Heptan-2-amine 1 was subjected to kinetic resolution, under orbital shaking for 7 h employing CALB and ethyl acetate as acylating agent, and converted into (R)-N- (heptan-2-yl)acetamide 5 (c = 42%, 88% ee p , hexane c = 52%, 81% ee p , isopropyl ether; c = 40%, 65% ee p , toluene). The reaction was fast (15 s) under microwave radiation in hexane and yielded acetamide 4 in high conversion (c = 91%), but without selectivity (5% ee p ).

Biocatalytic Acetylation of Primary Amines by Lipases under Orbital Shaking and Microwave Radiation