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Quinoline-3-carbaldehydes and their derivatives are recognized as starting precursors because of their broad range of synthetic versatility in organic chemistry. A diverse spectrum of interesting quinoline-based molecular architectures has been developed by the exploration of quinoline-3-carbaldehydes in the last years. In this context, ethanol-solvated methodologies demonstrate the exploration of quinoline-3-carbaldehydes towards the synthesis of quinoline and its scaffolds. This review covers the ethanol-solvated approaches for the development of quinoline derivatives through the synthetic exploration of quinoline-3-carbaldehydes.

Synthetic transformations of quinoline-3-carbaldehydes with ethanol as a green solvent