Open AccessA mathematical study of the adrenocorticotropic hormone as a regulator of human gene expression in adrenal glandsOpen Access
Author(s)
Manickam A.,
Jaison A. Benevatho,
Lakshmi D.,
Singh Ram,
Pravina C. T. Dora
Publication year2024
Publication title
computational and mathematical biophysics
Resource typeJournals
PublisherDe Gruyter
In this research, we have introduced compartments for asymptomatic and symptomatic individuals, along with reduced susceptibility, as key factors defining our investigation. The study is carried out in diverse scenarios, considering them as crucial for the essential generation number of the model, set at 3.18(r0>1{r}_{0}\gt 1). The persistent reproduction differential method was used to explore the impact of continuous adrenocorticotropic hormone (ACTH) administration on the global gene expression in primary cultures of both fetal and adult adrenal cells. The study also investigates ACTH’s genetic effects on both adult and fetal human adrenal cells. The conclusion of this study is demonstrated through relevant and correct medical applications.
Keyword(s)ACTH, asymptomatic, cortisol, estimation of parameter, enzymes
Language(s)English
eISSN2544-7297
DOI10.1515/cmb-2023-0122
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