English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The aim of this study is to load IR780 into an optimized micellar system that can act as a scaffold, and then test the anticancer activity and micelle stability in various media  in vitro . Poloxamer 407 was used as the primary polymeric surfactant. Micellar stability tests were carried out in three different media: distilled water, phosphate buffer saline, and Dulbecco’s modified Eagle’s medium (DMEM). The micelles were evaluated in terms of the micellar size, polydispersity index (PDI), zeta potential, and drug entrapment efficiency (EE). The micelles had an average size of 27.6–354.4 nm. The PDI for all of the micelles ranged between 0.23 and 0.28. The zeta-potential values were extremely low. EE was generally very high, exceeding 90%. Only DMEM showed significant shrinkage in the particle size during the first period of storage, reaching a range of 27.6–37.3 nm, followed by a gradual increase in the micelle size with time. The micelles significantly increased the activity on MCF-7 cells  in vitro . For more than a month, the micelles exhibited high stability in various media. The prepared system has a high potential for improving anticancer activity against a wide range of cancer cell lines.

Near-infrared IR780 dye-loaded poloxamer 407 micelles: Preparation and in vitro assessment of anticancer activity