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A nutraceutical self-nanoemulsifying drug delivery system (nutraceutical-SNEDDS) fortified with turmeric oil was developed in the present study to enhance dapagliflozin (DG) dissolution and provide additional antidiabetic benefits. To achieve these objectives, different nutraceutical-SNEDDS formulations were prepared using various surfactants and cosurfactants. The prepared formulations were evaluated in terms of homogeneity, emulsification, and solubility. The selected optimum liquid formulation, composed of HCO 30, Imwitor 308, and turmeric oil (5:3.5:1.5), was solidified using different ratios of Neusilin US2 and UFL2. The optimum solid nutraceutical-SNEDDS was characterized using Zetasizer, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffractometry (PXRD), and dissolution testing. The optimum formulation (S4) was prepared using a Neusilin US2 adsorbent (1:1). The dispersed S4 formulation showed nanometer-sized emulsion droplets (40.8 nm) with a negative zeta potential (−19.0 mV). SEM, FTIR, and PXRD analyses confirmed the successful adsorption of SNEDDS and drug amorphization without chemical interaction. Dissolution studies showed that S4 achieved comparable drug release to Forxiga with dissolution efficiency values of 88.7 and 90.8%, respectively. The prepared nutraceutical-SNEDDS is proposed as a potential enhancer of DG bioavailability and its therapeutic activity, leveraging the combined pharmaceutical and nutraceutical benefits of turmeric oil.

Turmeric oil-fortified nutraceutical-SNEDDS: An approach to boost therapeutic effectiveness of dapagliflozin during treatment of diabetic patients