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N‐Methyl‐D‐aspartate ( NMDA ) receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different  NMDA  receptor subtypes which differ in their single‐channel conductance. Recently, synaptic plasticity has been studied in the mouse barrel cortex, the primary sensory cortex for input from the animal's whiskers. Pharmacological data imply the presence of low‐conductance  NMDA  receptors in spiny stellate neurons of cortical layer 4, but of high‐conductance  NMDA  receptors in pyramidal neurons of layer 2/3. Here, to obtain complementary electrophysiological information on the functional  NMDA  receptors expressed in layer 4 and layer 2/3 neurons, single  NMDA  receptor currents were recorded with the patch‐clamp method. Both cell types were found to contain high‐conductance as well as low‐conductance  NMDA  receptors. The results are consistent with the reported pharmacological data on synaptic plasticity, and with previous claims of a prominent role of low‐conductance  NMDA  receptors in layer 4 spiny stellate neurons, including broad integration, amplification and distribution of excitation within the barrel in response to whisker stimulation, as well as modulation of excitability by ambient glutamate. However, layer 4 cells also expressed high‐conductance  NMDA  receptors. The presence of low‐conductance  NMDA  receptors in layer 2/3 pyramidal neurons suggests that some of these functions may be shared with layer 4 spiny stellate neurons.

High‐ and low‐conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex