Open AccessComparison of effects of high and low dose paracetamol treatment and toxicity on brain and liver in rats
Author(s) -
Ersoy Öksüz,
Semih Yaşar,
Remzi Erten,
Okan Arıhan,
Gökhan Oto
Publication year - 2020
Publication title -
i̇stanbul kuzey klinikleri
Language(s) - English
Resource type - Journals
ISSN - 2148-4902
DOI - 10.14744/nci.2020.54926
Subject(s) - toxicity , liver toxicity , medicine , pharmacology
Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.