Open AccessIL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response
Author(s) -
Ahmet Eken,
Zehra Okus,
Şerife Erdem,
Zehra Büşra Azizoğlu,
Yeşim Haliloğlu,
Ayten Bicer,
Tugba Nur Gur,
Ebru Yılmaz,
Musa Karakükçü,
Hamiyet Dönmez-Altuntaş,
Halit Canatan
Publication year - 2019
Publication title -
i̇stanbul kuzey klinikleri
Language(s) - English
Resource type - Journals
ISSN - 2148-4902
DOI - 10.14744/nci.2019.38802
Subject(s) - curdlan , cytokine , peripheral blood mononuclear cell , dendritic cell , flow cytometry , immunology , granulocyte macrophage colony stimulating factor , monocyte , cd14 , microbiology and biotechnology , t cell , chemistry , biology , antigen , immune system , in vitro , biochemistry , polysaccharide
In this study, we aimed to assess the effects of long- and short-term IL-15 cytokine exposure of human monocyte-derived curdlan-matured dendritic cells (DCs) on the production of Th17 cell-polarizing cytokine IL-23 and subsequent Th17 cell activation.