Open AccessIn vitro Mitigation of Arsenic-induced Toxicity by Reduced Glutathione in Rat Pulpal Cells
Author(s) -
Mohannad Nassar,
Ahmad Dargham,
Noriko Hiraishi,
Yukihiko Tamura,
Junji Tagami
Publication year - 2020
Publication title -
european endodontic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.302
H-Index - 6
ISSN - 2548-0839
DOI - 10.14744/eej.2020.26878
Subject(s) - glutathione , viability assay , toxicity , cytotoxicity , arsenic trioxide , mineral trioxide aggregate , chemistry , arsenic , andrology , pharmacology , in vitro , microbiology and biotechnology , toxicology , biochemistry , biology , medicine , dentistry , apoptosis , enzyme , organic chemistry
Despite the controversial results regarding the amount of arsenic (As) in mineral trioxide aggregate (MTA) and MTA-like cements, it is prudent to assess the effect of this heavy metal on pulpal cells and search for methods to attenuate its toxicity. This study investigated the toxic effect of As on pulpal-like cells and evaluated the influence of reduced glutathione (GSH) on As-induced toxicity.