Open AccessMacrophage Activation in COVID-19 Patients in Intensive Care Unit
Author(s) -
Guylaine Labro,
Louise Marie Jandeaux,
Andreea Rusu,
Edouard Virot,
Valentin Pointurier,
Luis Fernando Pinto,
Cyrille Mathien,
Agathe Debliquis,
Inès Harzallah,
Joy Mootien,
Bernard Drénou,
Khaldoun Kuteifan
Publication year - 2020
Publication title -
journal of medical cases
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1923-4163
pISSN - 1923-4155
DOI - 10.14740/jmc3520
Subject(s) - medicine , hemophagocytosis , hemophagocytic lymphohistiocytosis , macrophage activation syndrome , bone marrow aspirate , intensive care unit , covid-19 , macrophage , immunology , presentation (obstetrics) , intensive care medicine , bone marrow , surgery , disease , pancytopenia , arthritis , infectious disease (medical specialty) , biochemistry , chemistry , in vitro
We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).