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Validation of a Modified Version of the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score
Author(s) -
Blake T. Langlais,
Gina L. Mazza,
Heidi E. Kosiorek,
Jeanne Palmer,
Ruben A. Mesa,
Amylou C. Dueck
Publication year - 2021
Publication title -
journal of hematology
Language(s) - English
Resource type - Journals
eISSN - 1927-1220
pISSN - 1927-1212
DOI - 10.14740/jh914
Subject(s) - myeloproliferative neoplasm , medicine , myelofibrosis , essential thrombocythemia , quality of life (healthcare) , cronbach's alpha , physical therapy , polycythemia vera , distress , psychometrics , clinical psychology , bone marrow , nursing
Patients with myeloproliferative neoplasms (MPNs) suffer from chronic and progressive symptom burden. MPN trials capturing patient-reported symptoms routinely administer the MPN Symptom Assessment Form (SAF). The MPN-10 assesses 10 of the most clinically relevant symptoms, including fatigue and generates a Total Symptom Score (TSS). The original MPN-10 included a fatigue item from the Brief Fatigue Inventory (BFI). The myelofibrosis-specific symptom assessment tool called the MFSAF v4 utilizes a fatigue item developed to be consistent with other items within the SAF. This study sought to validate a modified version of the MPN-10 TSS using the SAF fatigue item for harmonization with MFSAF v4.

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