Open AccessComparative Effectiveness of a Six-Week Treatment Course of Vitamin D2 and D3 in Children With Sickle Cell Anemia in Steady State With Hypovitaminosis D: A Randomized Clinical Trial
Author(s) -
Motunrayo Oluwabukola Adekunle,
Akinola Dada,
Fidelis O Njokanma,
Adaobi Solarin,
Barakat Adeola Animasahun,
Moriam Omolola Lamina
Publication year - 2021
Publication title -
journal of hematology
Language(s) - English
Resource type - Journals
eISSN - 1927-1220
pISSN - 1927-1212
DOI - 10.14740/jh817
Subject(s) - medicine , vitamin d and neurology , vitamin d deficiency , rickets , vitamin , hypovitaminosis , anemia , alkaline phosphatase , gastroenterology , endocrinology , cholecalciferol , randomized controlled trial , bone density , osteoporosis , chemistry , biochemistry , enzyme
Correction of vitamin D deficiency through administration of either vitamin D 2 or D 3 has been shown to reduce chronic bone pains and frequency of acute bone pains, increase bone density as well as improve growth stature in children with sickle cell anemia (SCA). Findings vary on the effectiveness of the two forms of the vitamin. The current study was carried out to compare the effectiveness of a 6-week treatment course of vitamin D 2 and D 3 in the correction of hypovitaminosis D (vitamin D insufficiency and deficiency) as well as evaluate treatment response to derangement of serum calcium and alkaline phosphatase (ALP) in children with SCA in steady state.