Open AccessFecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection: A Four-Year Single-Center Retrospective Review
Author(s) -
Muhammad Farhan Ashraf,
Omar Tageldin,
Yousef Nassar,
Asra Batool
Publication year - 2021
Publication title -
gastroenterology research
Language(s) - English
Resource type - Journals
eISSN - 1918-2813
pISSN - 1918-2805
DOI - 10.14740/gr1436
Subject(s) - medicine , clostridium difficile , cecum , single center , incidence (geometry) , diarrhea , retrospective cohort study , fecal bacteriotherapy , transplantation , antibiotics , surgery , gastroenterology , physics , optics , microbiology and biotechnology , biology
Clostridium difficile infection (CDI) is a common cause of hospital and community-acquired diarrhea with an annual incidence of 453,000 cases in the USA. The white race, female gender, and age over 65 years are known risk factors. Recurrence of CDI is a major problem in patients taking antibiotics for prolonged periods. These patients are observed to have reduced diversity of the intestinal microbiome. Fecal microbiota transplantation (FMT) can restore the healthy flora in the gut, thus breaking the cycle of recurrent infection. Our study aimed to analyze the efficacy of FMT and the recurrence of CDI after FMT. We also aimed to investigate the effects of comorbidities on the outcome of FMT.